Endocrine Abstracts

Introduction: Chronic autoimmune thyroid disease (ATD) or Hashimoto thyroiditis (HT) is one of the main thyroid diseases in pediatric age. HT characterized by the production of anti-thyroid antibodies, by an infiltration of autoreactive B and T lymphocytes into the thyroid parenchyma and by alterations in thyroid function. Coeliac disease (CD) is a systemic autoimmune disease caused by gluten ingestion in genetically predisposed subjects. At presents with a pathognomonic enter...

The aim: To estimate secretory and proliferative activity of pituitary adenoma (isolated somatotropinoma (ST) and somatomammotropinoma (SMT).Subjects and methods: The study included 133 patients (total group: 45 male/88 female), aged 44.0±12.5 year old with acromegaly (95 – with ST and 38 – with SMT). There were estimated patient’s age, age of manifestation of acromegaly (agemanifest.), duration of period before diagnosis (...

IntroductionThe practice of screening for many chronic diseases, particularly endocrine pathology, is taking place all over the world. The relevance of screening increases significantly when we are talking about diseases with a torpid manifestation and absence of certain clinical symptoms in the debut. Such diseases include pathological conditions caused by pituitary hormone hypersecretion, in particular, acromegaly.The aim<p c...

IntroductionVitamin D (VitD) is thought to be essential for adequate testosterone (T) secretion in men. In the absence of D-hypovitaminosis, their blood T levels and T to estradiol (E2) ratio values are higher relative to those with VitD deficiency. The correlation between VitD levels and androgenization indices in men of different ages has not been practically studied.The aimTo study blood levels of T and th...

Aim: The aim of the study was to investigate the clinical and hormonal effectiveness of different modes of suppressive cabergoline (CAB) therapy during 12 months in patients with prolactinoma.Subjects and methods: It was examined and underwent a 12 month course of treatment by selective dopamine agonist CAB in 61 patients with prolactinoma (PROL) (9 male/ 52 female) aged 16–66 years. There were 40 women with microPROL, 12 with macro&giant PROL; ...

Introduction: Acromegaly (ACRO) is a rare disease of an excessive somatic growth and distorted proportions arising from hypersecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). The aim Of this study is to investigate basic demographic parameters such as the age and gender related features, age at diagnosis of the disease, its clinical manifestations, biochemical control and structure of complications in Ukrainian patients with ACRO in a single neuroendoc...

Introduction: The role of the pineal gland and its hormone, melatonin, in the regulation of hypothalamo-adenohypophysial system activity is well known. At the same time, studies of the circadian rhythm of melatonin secretion in patients with pituitary adenomas are few in number, because the evaluation of pineal activity is not generally included in the clinical investigation of patients with pituitary tumors.Aim: The present study analyzed the circadian ...